Hard truth about what happens when you stop weight loss injections

  • Lata Mishra
  • TIMESOFINDIA.COMUpdated: Jan 27, 2026, 21:10 IST IST
GLP-1 weight-loss drugs such as semaglutide and tirzepatide have been hailed as breakthrough treatments for obesity, helping people shed 10-20% of their body weight really quickly in clinical trials. But a growing body of evidence — and now real-world experience in Indian clinics — suggests that the benefits may be difficult to sustain once the injections stop.
Studies show that many patients begin regaining weight within months of discontinuation, often putting back a substantial portion of what they lost just as quickly as they shed it.
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